He aha te Tangohanga Citrus Aurantium He Tohunga Taiao mo te Ture Kena me te Metabolic? - He -Taritanga Hohonutanga o ona Hanganga Maha-Me te Uara Haumanu

1. Whakamaramatanga Putaiao me nga Taketake o mua o te Tangohanga Citrus Aurantium

Ko te tangohanga Citrus aurantium he roopu o nga waahanga kaha i whiwhi mai i tenga hua maroke marokeo Citrus aurantium L. Citrus sinensis Osbeck ranei (whanau Rutaceae) na roto i nga tikanga tangohanga hou. Ko tana whakamahinga rongoa i hoki mai ki:

"Shennong Ben Cao Jing"(Eastern Han Dynasty): Kua whakarōpūtia hei otaota -waenganui, kua rekotia hei "mate i te hau kino i roto i te kiri me te whakatau i te makariri-te wera."

"Shang Han Lun"(Zhang Zhongjing): I whakamahia hei otaota rangatira i roto i nga tauira tawhito penei "Da Cheng Qi Tang."

Nga Paerewa Pharmacopoeia Hou: Ko te 2020 Hainamana Pharmacopoeia e whakaatu ana i te iti o te hesperidin he 4.0%.

2. Te Taatari Nahanaha o nga Waahanga Matua

2.1 Alkaloids

2.2 Flavonoids

CompositionHesperidinNeohesperidinNaringinNobiletin

Hesperidin: Ka aukati i te intestinal -glucosidase (IC50=28μM)

Nobiletin: Whakahohehia te ara AMPK -SIRT1-PGC1 (whakanui ake i te biogenesis mitochondrial)

2.3 Hinu Hurihuri

d-Limonene (32.6%): Whakatairanga i te hunanga o te papa (e whakawhirinaki ana ki te horopeta-)

-Terpinene (18.4%): Ka aukati i te tipu H. pylori (MIC=62.5ug/mL)

3. Hangaia-Maama o te Mahi

3.1 Whakahaerenga Pūnaha Digestive

Whakarei ake i te Motility Gastric:

Ka whakanui ake i te kaha o te whakahekenga antral (+40%) mā te tuku cholinergic neurotransmitter

Ka whakaheke i te haurua haurua-te wa putua (mai i te 45min→28min)

Ko te Hunga Microbiota Modulation:

Whakanuia te tatau Bifidobacterium/Lactobacillus (3-5x)

Whakahekea te ōwehenga E. coli (↓60%)

3.2 Whatunga Whakaritenga Metabolic

4. Pūnaha Mana Kounga

4.1 Mana Rawa Rawa

Wā hauhake: 1.5-2cm te diameter o nga hua (te nui o te flavonoids)

Te takenga matawhenua: Jiangxi (rohe whakangao pono) e 30% teitei ake nga flavonoids

4.2 Tukanga Whakaputa

I mua i te -maimoatanga: He iti-mahana kuru (<40°C)

Tangohanga: Tangohanga waiwaro kua tohua (50%→70%)

Te purenga: Te urunga kapia Macroporous (momo AB-8)

4.3 Tawhā QC

Ko te ritenga o te matimati Chromatographic He nui ake, he rite ranei ki te 0.95

Nga konganuku taumaha: Pb<5ppm, As <2ppm

Pesticides: BHC<0.1mg/kg

5. Raraunga Rangahau Haumanu

5.1 Kore Mahi (RCT)

Hoahoa: Taurua-matapo te whakahaere (n=240)

Hua:

Reeti whakaora tohu: 82.5% ki te whakahaere 58.3% (wh<0.01)

Electrogastrogram: Whakapai ake te manawataki i muri i te kai +35%

5.2 Metabolic Syndrome (Meta{1}}Atatari)

12 nga rangahau i whakauruhia (1,842 nga keehi)

Putanga:

Porowhita hope: -3.8cm (95%CI:-4.2~-3.4)

Te hukahuka nohopuku: -0.82mmol/L (p=0.003)

6. Kawa Tono Tikaols

6.1 Inenga-Whakautu Hononga

6.2 Whakakotahitanga Whakakore

Tupato me:

Ephedrine-kei roto i nga raau taero (kei te whakarei ake i nga paanga ngakau)

Anticholinergics (kei te whakaiti i te kaha)

6.3 Taupori Motuhake

Kaumātua: Tīmata i te 50% te horopeta paerewa

Haputanga: Karekautia (kei te whakaihiihi i te whakaheke o te uterine)

7. Aratohu Aromātai Hua Maakete

7.1 Nga waahanga hua tino pai

Kua tapaina he takenga "whenua tūturu-puukau".

Ka whakarato i te tapumati HPLC

GMP-tohu

7.2 Tikanga puremu noa

Kua taapirihia te synephrine waihanga

Whakaranuhia ki te tangohanga kiri tangerine

8. Hunga-Ahunga Rangahau

Tuaka roro -gutu: Paanga ki nga kaiwhakawhiwhi 5-HT

Te kaha o te mate pukupuku: Wnt/ -te arai arai catenin

Nga punaha tuku hou: Nanoemulsions mo te pai ake o te koiora

Whakamutunga

Ko te tangohanga Citrus aurantium ka noho hei kaiwhakahaere maori e kore e taea te whakakapi i roto i te -te hauora o te nakunaku ma te:
1️⃣ Hunga-maha(alkaloid-flavonoid-whakatoru hinu wariu)
2️⃣ Maha-mahi whainga(whakarerekenga mate-metabolic-
3️⃣ Te horopeta tika(nga tikanga kua whakamanahia e te haumanu)

Mo nga hua tino pai, tohua nga hua mai irauemi matawhenua tūturu-ma te tangohanga paerewa, me te whai i nga tikanga whakamahi whaiaro