1. Tuakiri Molecular
Ko Oleuropein hesecoiridoid glycosidekitea ahurei i roto i:
Rau Oriwa (6-9% ihirangi)
Te hinu oriwa wahine hou (ina koa te hauhake-toata)
Epidermis hua oriwa
Teneiphenolic kawaka whakamārama te pūhui i teRohe KahurangiKo nga painga mo te wa roa ka kitea i roto i nga taupori Mediterranean.
2. Takitoru-Mahinga Mahi
Painga Cardioprotection:
Whakarei akete whakahohenga eNOS(300% KORE whakanui)
Taiaote aukati ACE(angiotensin blockade)
Te Mana Mitochondrial:
AMPK phosphorylation ↑150%
Matatini I/III kaha +35%
Whakawaenga Epigenetic:
Kīanga SIRT1 ↑2.1-fold
NF-κB pehanga (IL-6 ↓60%)
3. Paerewa Koura Haumanu
Kawa Motuhēhēnga:
HPLC -PAPAmo te oleuropein aglycone
NMRte whakapumautanga o te hanganga ngota
LC -MS/MS purity verification (>98%)
Tauranga Pumau:
pH 5.2-6.8 wairewa wai
Avoid >60 tohu tukatuka
He mea nui te takai karaihe pouri
4. Te Huarahi Pharmacokinetics
Nga Pūnaha Tuku Korero:
Cyclodextrin complexes(wai wairewa ↑900%)
Whakapiri Transdermal(72-haora tuku tonu)
Nanoemulsions sublingual(Tmax<15min)
Nga Ara Metabolite:
→ Hydroxytyrosol (puka hohe)
→ Oleacein (anti-inflammatory)
→ waikawa Elenolic (antimicrobial)
